Systematic studies genetically inhibiting mTOR in specific tissues to determine lifespan/healthspan impact have not been performed in mammals.

“I don't Matt I don't think that study has been done right not systematically there's a little bit of data on hypomorphic uh mtor um and gosh I wish I could remember the outcomes of these yeah know there's been a little bit Veronica galvin's done some stuff for dementia brain aging um I don't know about lifespan I think and finle may have done something but I I but but in general it has not been done outside of you know if it's been done there was like a adapost specific knock down knockout I and uh maybe liver specific but certainly not systematically looking across different tissues”