Mutations in the mitochondrial genome could potentially be presented as tumor antigens and may be more immunogenic.

“what about mutations in the mitochondrial genome so one of the mouse models we made was to generate a mutator Phoenix in the mitochondrial genome there are human cancers that have a high level of mitochondrial genome mutations whether that has any effect on anything is completely unknown there's no reason why they couldn't be presented as tumor antigens and you'd think if anything they would be more immuno genic”