Peter Attia· MD
we think that senescence cells could be driving this disease
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we think that senescence cells could be driving this disease
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our theory about what's going on in osteoarthritis and this is just one of the ideas we entertain here and I can explain what data we have that supports this notion is that senescence cells accumulate at sites of osteoarthritis in fact they may be trying to heal got it but unlike in the skin they literally fall off in the context of healing this cells remain and essentially continue to sound the alarm over and over and over again and we think it could be giving a sort of flawed attempt at wound healing that could be driving the pathophysiology of disease
there are a lot of them at the site where you have the osteoarthritic injury and you go millimeters away and then it drops way down
they started growing cartilage in the plastic dish so these are cells that came from the sick person's knee they had the capacity to make cartilage but they just didn't but once you eliminated the cells all of a sudden they were producing cartilage again
if you were on a little mini nano spaceship and you were inside the joint of a person with osteoarthritis you wouldn't be able to look out and see which of the cells are actually senescent and which ones are normal which ones are simply injured you wouldn't be able to make that distinction
we saw that the more senescence cells they had the worse osteoarthritis they had the more bone deformation they had in the knee the more pain they had
if you look it to the synovial membrane which is I'll talk to you about another study we did in humans where we actually counted senescence cells in patients with osteoarthritis the number hovers around one to two percent
when we induced trauma by cutting the ACL which is known to be risk factor for human osteoarthritis of the knee we got something that looked like osteoarthritis and we eliminated senescence cells either genetically or with our drug in which we've now taken into human beings we could in this trauma-induced setting
it scales with you have more senescence cells when you have more disease
Selectively removing old or senescent cells from joints could stop & reverse the progression of osteoarthritis.