The ideal experiment to validate epigenetic clocks involves measuring blood epigenetic age in mice, applying lifespan-extending interventions, and tracking survival and pathology.

“if the clocks are working you should absolutely be able to detect that signature well in advance of end of life right and I think that would you know if somebody did that experiment and it worked I would be convinced that would that would make me really be a believer you know in in the epigenetic clocks”

“if somebody let's say at Altos publishes a paper three years from now that they have made a mouse live six years by multiple rounds of transient epigenetic reprogramming I'll be like their biggest fan they moved the needle that convinces me that that strategy modulates biological aging nobody's done that yet”