The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we know that the presence of ketones specifically beta-hydroxybutyrate actually turns on longevity genes and all the buzz right now is this buzz about caloric restriction and the benefits of caloric striction and all these fancy molecules which mimic caloric restriction but as you and I have talked about they're actually just fairytales they don't really do it that well
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Fox o3 is one of the genes that is turned on by beta-hydroxybutyrate
the beta hydroxybutyrate has also been shown to potentially be a histone d acetylase inhibitor have this sort of epigenetic modification capabilities and h the beta hydroxybutyrate can turn fox03 on as well
I'm very interested in beta-hydroxybutyrate as not only as a source of energy for mitochondria. So being able to be converted into a thermodynamically favorable source of energy, but also the fact that it's able to change cell signaling in the brain and it's able to turn on genes that are involved in dealing with stress better, some of these genes are involved in longevity, FOXO3 for one.