Amplification of MYC, loss of p53, and mutations in the P10-AKT pathway are associated with lethal cancers.

“the general genetic trait associated with that transition from localized to localized with lethal potential is an is something to do with the P10 akt pathway sure and that doesn't mean that you have a lethal tumor if you have P10 loss but it in my mind it begins to open up the book to say lots of other mischief and nonsense can go on within the tumor we know from lots of studies that if you have loss of p53 for example that that's associated with lethal prostate cancer amplification of Mick lethal cancer in general yes exactly amplification of Mick is another one too”