Arthritis involves cartilage thinning where chondrocytes can die or enter senescence under significant load or overload.

“so arthritis is is part of arthritis is the loss of that cartilage the cartilage starts to thin um the condra ites which are the main cellular is the cell of cartilage its job is to create proteins to make the extracellular Matrix so that it remains healthy but condra sites that the the cartilage itself is avascular and they're not very efficient at making The extracellular Matrix which is imperative so if there is any un if there's overload of the cartilage the condra sites will respond and sometimes they die sometimes they go into sence”