The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so so that study so everolimus is a derivative of rapamycin and and biochemically it has exactly the same mechanism so it's i at least i conceptually think about them as essentially the same molecule so so anything that we see with ever alignments we would expect to see with rapamycin and so that was a phase two clinical trial in healthy older adults to look at whether or not a six-week uh treatment with everelymus could boost uh vaccine response
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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what they showed i mean obviously it's people so you can't do the mouse experiment and then give those people a lethal dose of influenza so they were sort of you know stuck with looking at things like antibody titers and to to try to get an assessment of you know did the people who got um ever alignments respond better to the vaccine than the people who got the vehicle control and it looked like they did and it was you know you can argue about the the strength of the data i think it was pretty clear that they had um at least at the the the five mig once a week and i think the one mig daily i can't remember maybe it was the 20 mig once a week but the five meg once a week looked pretty convincing that they had a better response to the to the vaccine
the first paper what the first paper showed was I think pretty convincing data that at least at the five milligrams once a week and one milligram daily dose there was a boost in response to the vaccine as measured by antibody tighters so that supported the idea that similar to what had been shown in mice you could in fact to some extent rejuvenate the ability of the Aged immune system in humans to respond to a vaccine um with transient dosing with a Romy derivative ever in this case
we have this one study using everus that show that gives us a hint that says hey this might actually enhance immune function in people in their mid-60s