Lis syndrome is a rapid neurodegeneration characterized by lesions in the brainstem, basal ganglia, and sometimes the spinal cord, leading to a quickly fatal outcome.

“subacute degeneration of the gray matter it's a very rapid neuro degeneration it's a terrible terrible disease and what age are people when they start to experience this neuro degeneration so most of these kids are actually born developmentally Wow and then within the first couple of months of life there's some sort of a stressor sometimes it's some sort of an infection sometimes it's a dehydration that'll put them into a neuro metabolic crisis and at that point if you look at their brain of our eyes you'll see lesions in the brainstem the basal ganglia sometimes the spinal cord corresponding to regions of necrosis Wow so quickly fatal”