Prostate tumors with gene expression signatures reflecting very low Androgen Receptor signaling and amplification of PTEN and MYC are associated with a more aggressive phenotype, including metastasis, progression, and resistance to traditional therapies.

“so they tell us that there within a within a prostate cancer agnostic of grade agnostic of stage there are tumors that have signatures that are consistent with high Androgen receptor output those would be like like the way I explained to patients are those are weeds in your garden that have just they're really large above the surface but have very thin tiny Roots they're they're very they're very um they're very U they're kind of differentiated right they're big and they're well differentiated but they're not aggressive and then there are tumors that have you know they don't look like a normal prostate gland at all and they are have signatures that are that reflect very low Androgen receptor signaling they have amplification of other signaling Pathways P10 uh Mick Etc”