Extremely small p-values from large databases may reflect bias rather than a true finding.

“there's many many fields that you can easily get p-values that are astronomical they're not just less than 0.005 but they may be 10 to the minus 100 with some of the large databases that we have we can easily get to astronomically small p-values but this doesn't mean much it could just mean that you have bias and this is why you get all these astronomically low p-values but they don't really mean that the chance of getting such an extreme result is is extremely implausible and that there's something there it just means that certainly there's bias no more than that”