Chronic scalp tension can lead to fibrosis and increased TGF-beta 1, similar to processes in other tissues.

“what happens with tension-mediated environments or pressure-mediated environments or inflammation mediated environments in other tissues of the body well in the prostate pressure induces dht transforming growth factor beta 1 and scarring or fibrosis it's the same things that you see in a balding scalp you see fibrosis at each stage of hair follicle mitralization alongside those other mediators in dubois trans contracture when people have a tendon that contracts like this and it gets stuck you see increased antigen activity increased transforming growth vector beta 1 increased fibrosis same in the balding scalp well if you look at the eyelids of patients with graves disease where they retract you look at that chronic contracted eyelid it's the same exact signaling proteins”