Clinical trial endpoints can be ranked in order of specificity and ease of measurement, from all-cause mortality down to cholesterol changes.

“So you're tra when you do clinical trials you trade off between outcome and barrier to outcome for lack of a better term right so if you want to use all cause mortality that is the that is the ultimate measuring stick but it's a high bar to clear. So then you can go disease specific mortality. Okay, we're now going to look at major adverse card or sorry coronary death. Great. Then you can go one step lower and an example would be mace major adverse cardiac event where we're going to use heart attack and stroke and cardiac death. Um, then you can go one step below that and say well we're just going to look at a change in cholesterol or we're going to look at a change in LDL cholesterol.”