Antagonistic pleiotropy suggests traits beneficial in youth can be detrimental in older age, potentially explaining how cellular stress responses disrupt chromatin and cause gene misregulation.

“the problem we think is it's antagonistic pleiotropy okay so Peter Medawar and the other brilliant scientists in the 50s speculated I think correctly is that things that are really good for you when you're young come back to bite you in the ass when you're older and I think that's what's happening here is that this response to these stressors like a break end up not just distracting these proteins but end up disrupting the actual structure of our chromatin and these proteins don't always go back to where they came from a hundred percent do that for 70 or 80 years and it's not surprising that the genes that were once perfectly programmed and turned on at the right time lose their ability to do that”