Leucine and arginine are transported into cells via high-capacity transporters and bind to cytosolic receptors that activate mTORC1.

“In 2015, in the fall, you had these two papers that came out that looked at leucine, of course, huge interest, but also arginine. Leucine and arginine can get into a cell very easily. Do they passively diffuse in? There's transporters. Relatively straightforward transporters. But they're a high -capacity transporters. Okay. In the cytosol, these amino acids bind to receptors that then downstream result in the activation of TOR. MTOR 1.”