Peter Attia· MD
what we care in medicine is clinical significance meaning if i do something or if i don't do something would that make a difference to my patient or it could be in public health to the community to cohorts of people to healthy people who want to have preventive measures and so forth do i make a difference does it matter is it big enough that is worthwhile the cost the potential harms the implementation effort perhaps other alternatives that i have how does that compare to these alternatives maybe they're better or cheaper or easier to implement or have fewer harms