Rhonda Patrick· PhD
Disruption of the gut barrier & microbiome may be primary cause of age-related inflammation which accelerates aging.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Disruption of the gut barrier & microbiome may be primary cause of age-related inflammation which accelerates aging.
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And inflammation accelerates that process. It causes more damage. And the major source of inflammation in the body is the gut. Not only because it regulates the immune system, but also because it is where we have all the bacteria. It's where our largest concentration of immune cells actually are. So when we start to have an unhealthy gut, when the gut barrier breaks down for several different reasons, then our immune cells go crazy, start firing cytokines, which are inflammatory, you know.