Measuring only a single cord blood sample for acetaminophen exposure is insufficient to predict overall annual consumption or reliably impute risk for conditions like heart disease.

“using this single sample of cord blood um which may have some association with maternal use during pregnancy but is very unlikely to account for the actual nuanced differences in dose and exposure during pregnancy. Again think about that through the lens of any other thing. If I if I could only measure how many donuts you ate on your birthday, it would be very difficult for me to impute how many donuts you eat over the course of a year. Would it have a correlation? Probably. But it wouldn't be strong enough to take to the bank if I was trying to use doughnut consumption um as a as a marker of predicting heart disease.”