The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
clotto basically killed seemed to kill 50 of our subjects by age 85 okay the genotype has disappeared by age 85. and all of a sudden after that at 1800 it was the same okay it was the same and our interpretation was that you know those centenarians were born with clutter but they were also born with longevity genes which made the the clutter not significant
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clotto basically killed seemed to kill 50 of our subjects by age 85 okay the genotype has disappeared by age 85.
and those people end up having multiple disadvantages in lifespan and um vulner ability to different diseases so when we talk about KVs we're talking specifically about heterozygosity carrying one Al of it sorry what what are some of the health consequences of being homozygous and what is the prevalence of homozygosity it's really rare So if the prevalence of heterozygosity is um around 25% in populations homozygosity is so it's probably about 1 to 2% because actually it would kind of mirror APO E4 where the heterozygosity is about the same right it's about one in four and the homozygosity is about one in one in 50 to one in a 100 yeah that's about right um it it is it's pretty rare but it exists and and um those people have shorter lifespans they have much lower levels of clotho um and they are at risk for anything that the heterozygosity helps with the homozyg homozygosity hurts
the discovery of clotho in 97 which was based on effectively a knockout um we saw that that that is incompatible with a long life