Sirtuins, mTOR, and PGC-1α pathways are considered longevity pathways that evolved for survival during adversity, not longevity itself.

“their job is to allow that organism to hunker down and survive stop mating stop breeding we can do that in another day if we don't survive this our offspring ain't gonna die anyway so they can't we think we control which genes to turn on and off in response to adversity and they allow those organisms to survive but they're also talking to other pathways so they're gonna talk to em - are they going to talk to Cynthia's deaf pathway”