Editing the APOE4 allele to APOE3 or APOE2 can be considered an enhancement, as these alleles are associated with lower risk for conditions like Alzheimer's disease.

“Correct. So that's somewhat...depending on how you look at the composition of various genes, now that particular case E4 is not the predominant allele. And so you might call it an enhancement. PCSK9 is very rare in the population, and so if you make everybody or a large fraction of population PCSK9 negative, that could be called an enhancement relative to the average. But it's not an enhancement relative to the minority. In the case of APOE3 or even APOE2, which is...that is rare than the E3 plus E4, and that would be an enhancement. But E3 over E4 is probably about closer to average.”