Epidemiologic questionnaires are an unreliable method for predicting longevity phenotypes due to issues with dose, specificity, quantity, and quality of exercise data.

“so you are now stuck using something I think I recently described as the most servile trash ever shat into civilization which is epidemiologic questionnaires to try to impute based on you know you telling me how you've exercised over the past 10 years how that's going to predict your longevity phenotype and again the problem there is the dose matters the specificity the quantity the quality these things matter and they're very difficult to tease out from these retrospective views”