The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so I think all of us should be excited about this work because not only is this a solution so if our phase two replicates the phase one and which we all hope and believe it not to not only is this a means to treat the primary reason it hurts to be old but it's he read through to this whole idea of medicine which is could you treat
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the way we did the study was 48 patients where we did a three to one randomization meaning three people would get drug versus one person giving placebo and as you noted we stepped up in dose
what we show is that when we eliminate senescence cells from the painful knee joint of a human being with osteoarthritis a single administration of a sin oolitic medicine eliminates pain dramatically in these humans for as long as we've looked and so the cells we don't know if the cells have come back but we don't think they have come back by that time this sort of
what we saw in terms of the speed of pain resolution in the phase one was it within two weeks of the injection you achieved most of your pain reduction so it seems pretty implausible to me that that is the result of a structural change to your joint it seems far more likely this is the result of getting rid of factors that are driving pain acutely
we knew from animals that if we could induce surgical trauma to an animals knee a mouse and we eliminated senescence cells that we could eliminate pain and actually repair cartilage in a mouse
oh yes every it's called a double-blind study which means nobody knows who's got drug who's got placebo or what dose of drug you were on
exposure to the drug eliminated senescence cells that were very prevalent from this site of damage
this molecule is safe enough selective enough and potent enough that we can do it
we could drive that disease backwards in a mouse
we were able to demonstrate the Senna lytic molecule
in human beings we have eliminated senescent cells from patients knees with a single injection of this drug and we can not only eliminate or dramatically reduce pain
Selectively removing old or senescent cells from joints could stop & reverse the progression of osteoarthritis.