Peter Attia· MD
if you break up the interaction between mdm2 and p53 p53 doesn't get marked for destruction so it's concentration and the cell goes up
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you break up the interaction between mdm2 and p53 p53 doesn't get marked for destruction so it's concentration and the cell goes up
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The first molecule identified was a mdm2 p53 interaction inhibitor
so p53 goes up in concentration the senescence cells die selectively
when you did this to senescence cells senescence cells died preferentially