The AZE hypothesis suggests proline analog AZE can substitute for proline in myelin basic protein, causing misfolding and potentially contributing to multiple sclerosis.

“so he says here um that a the aze hypothesis posits that myelin basic protein protein within the um within the myelin sheath of a neuron is resembled by aze and possibly other closely related molecules are misassembled in sites of lesion formation because of the substitution of aze for one or more of the prolines within the consensual epitopes meaning these conserved domains of the myelin basic protein these include a highly conserved myelin basic protein hexapeptide sequence prt ppp and an alpha helix bounded by prolil residues”