Caloric restriction studies often normalize metabolic rate or muscle mass to body weight, which can obscure true caloric restriction.

“but usually these studies will be normalized to body weight”

“um but usually these studies will be normalized to body weight this actually comes up also in some of the um the intermittent fasting studies where you know the question sometimes in these studies is are they isocaloric or are they calorically restricted when they're put on intermittent fasting and um people claim they're isocaloric but the mice lose weight and what they really are is isocaloric when normalized body weight right so you know they're really calorically restricted but you have to kind of dig to to to to to get how the normalizations were done to really understand”