Peter Attia· MD
It's around 2002, right? So we were doing that around 2001, published around 2002. It's in that range. It's in the early 2000s.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It's around 2002, right? So we were doing that around 2001, published around 2002. It's in that range. It's in the early 2000s.
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But one of the things that was obvious to me and I think to others as well was that mTOR had to act with partner proteins. And so we set about trying to identify what we now know are these mTOR containing complexes, mTOR 1 and mTOR 2, mTOR complex 1 and 2.
david also played the fundamental role in elucidating that mtor can be organized in a couple of different ways and sort of two main different ways it can be organized known as complex one and complex two
mtor protein um acts in at least two i think there's only two that we know of uh two different complexes called mtor complex one or m torque one and mtor complex two or m torque two
another protein that we named RoR defines what we call M torque 2
when we moveed to other detergents use things to stabilize it we then found these Tor complexes all right and and the first breakthrough for us was the Discover of a protein that that got this name Raptor um which at the time people didn't like this name but now is is a well studied protein and as Matt alluded there's actually genetics on Raptor that connect it to to lifespan in the aging process and so that defined what we now call torque 1 or M torque 1 another protein that we named RoR defines what we call M torque 2 I'm sure we'll talk about mtor 2 at the time and so we started building out that complex and now when you had that thing in a test tube it did stuff like it could show serious activity that you could measure it could do serious phosphorilation the known substrates like S6 kyes that before we couldn't
and now when you had that thing in a test tube it did stuff like it could show serious activity that you could measure it could do serious phosphorilation the known substrates like S6 kyes that before we couldn't phosphor S6 KY to save our life inside a test tube now all of a sudden you really could
and now when you had that thing in a test tube it did stuff like it could show serious activity that you could measure it could do serious phosphorilation the known substrates like S6 kyes that before we couldn't phosphor S6 kind to save our life inside a test tube now all of a sudden you really could