Peter Attia· MD
the first that comes out is the igf insulin signaling pathway yeah which as you said goes all the way back to c elegans right
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the first that comes out is the igf insulin signaling pathway yeah which as you said goes all the way back to c elegans right
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I remember, in fact, one of my first experiments in biology was doing, you know, manipulating the IGF-1 signaling pathway in worms, in Andrew Dillin's lab at the Salk Institute. And I remember when I saw, you know, when you get rid of that pathway in these worms, they live 100% longer.
And to think that this is the same pathway that's conserved in humans, it's like, "Well, that seems very relevant."
One of the major pathways that has emerged is insulin signaling pathway. That was the work of Cynthia Kenyon back in 1990 showing that the insulin signaling pathway is one of the major pathways that controls aging.