Slowing the accumulation of biological damage may involve lowering 'noise' in biological systems.

“So maybe what you need to do when you're looking for longevity interventions is not looking for how long a worm lives because the worm is dying for a different reason. It's already in the failure mode. It's about how to lower the noise in the system. uh and lowering the noise in the system might be a way of of changing that slope. So that could be transcriptional noise. It could be anything you can measure as noise that happens over time. You might want to try to lower that noise.”

“Well I think the scary thing is that that that linear accumulation it does look like entropy which in reversing the second law of thermodynamics is we don't have to reverse it, we just have to slow it. Slow it. Even slowing it is a challenge, right?”