Parkinson's disease involves a loss of dopamine-producing neurons, with clinical manifestation occurring after 40-50% cell loss and 60-80% dopamine depletion.

“so the idea is that there is a special phenomenon with parkinson's and essentially um it is um dopamine dopamine loss is a big component of what manaf but with the manifestations of parkinson's disease uh we think about is actually about 40 40 let's say to 50 cell loss why and 60 to 80 percent dopamine loss”