The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
a nutshell mtor is the master integrator of external availability of nutrients and growth factors and then is the master regulator of the outputs of that integration deciding whether cells are going to make proteins make lipids make nucleic acids grow or are we going to circle the wagons conserve resources recycle and wait during times of little for hopefully future times of plenty so that's the role of mtor
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the signals it takes are amino acids glucose cellular energy growth factors from other parts of the organism as probably the major ones and then decides are there sufficient resources that the cell should grow or not
and I think that accounts for why mtor has so many different roles because if you think about our sort of evolutionary history there's almost nothing in our physiology that shouldn't be controlled by the availability of nutrients
at the end of the day what we conclude in a kind of big picture point of view is that this is the protein that links the availability of nutrients in our environment to whether we're in a catabolic or an anabolic State anabolism growth catabolism breakdown of material