Mouse models with varying mutation burdens in tumors are being developed to study the role of autophagy and immune system recognition.

“a big part in fact we just got an NIH grant to study this is to make mouse models of cancer with low medium and high mutation burden with which to you could hang out at offer G and exactly we haven't done the autopsy part yet we're just doing the generating the models using proofreading mutations in polymerase epsilon and Delta to generate mice with cancer with various levels of mutation burden in their tumors”