Paul Saladino· MD
but there is are there others like butyril all right carbonyl besides acetyl acetyl groups
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
but there is are there others like butyril all right carbonyl besides acetyl acetyl groups
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and so by doing this the sirtuins are affecting the epigenetics is that correct they're they're pulling off these these groups are they activating genes because i know that they activate the sirtuins activate fox03 pgc1 alpha these are super important oh yeah they're turning on genes is that what they're in silencing they're silencing they're silencing they're silencing proteins
Sirtuins are HD x is that correct are they all aged X so H DAC histone deacetylases this is the old name for protein deacetylases now because well we've all come to real as histones are just one of the things that sirtuins in these other HDX - they can target what are called non-histone proteins and remove not just a settle groups but also other types of what are called generally acyl groups
means that sirtuins the family there are seven of them in mammals five of them in yeast target other proteins proteins that are in cytoplasm in the nucleus even in the mitochondria and that's their role it's not so much only about controlling the chromatin and histone but also about controlling signaling and metabolism as well