Cumulative dosage, rather than single doses, often determines toxicity, as seen with mercury and fluoride.

“the truth is very that's that's true for a lot of things but very often it's the cumulative dosage that determines the poison you know there are safe levels of mercury there are safe level safe I'm saying you know CDC FDA levels of of of of mercury there safe levels of fluoride um but these the cumulative toxicity I mean nobody got mercury poisoning from eating one piece of tuna fish right right it had a safe level of mercury in it but if they ate it every single day the cumulative toxicity is what the problem is”