Peter Attia· MD
1 are these HLA alleles like this is the human history compatibility like this and there's there's certain alleles that are quite common in the population that when combined place people at higher risk and so there's something called HLA dr 3 and dr 4 and these alleles tend to run quite frequently in the u.s. population and as a result people who have type 1 diabetes typically will have about a tenfold risk of having a child with type 1 diabetes relative to the to the general population and to be clear is that assuming they inherit the same HLA type or independent of the inherited pattern of their HLA because if you're if you are HLA to dr your kid has a is that is that a co dominant inheritance is your kid 50 likely to get that assuming your wife doesn't have that yeah but what happens is it's so common that your wife may have that and so just statistically because children end up having it the people who have type 1 diabetes often have these alleles and also these other minor alleles that contribute each very small amounts but in aggregate quite a bit