The sirtuin genes, like SIR2 in yeast, respond to dietary restriction, heat, and starvation, allowing yeast cells to live approximately 30% longer.

“what was controlling aging in yeast in part were these sirtuin genes now sirtuins in science in an aging pretty famous but what a lot of people don't know is that the word sirtuin stands for gene called co2 which in yeast we found responds to dietary restriction heat starvation and it allows the East to live about 30% longer if you up regulate it or put just another copy of that gene in the yeast cells and make cable line who's now a famous professor he was the graduate student who did that experiment to put extra sort of gene into yeast and they live longer”