Peter Attia· MD
for example mitochondrial injury that is a reversible genetic mutation that is unfixable like what are the suite of things that basically take a cell down the path of I can't fix this and being around here and replicating is going to be dangerous to the host I got to take myself out of the game right so mitochondrial damage in certainly trigger apoptosis but probably the best way to explain it is by using the example of p53 so p53 is a tumor suppressor and a transcription factor and some of the transcriptional targets of p53 are proteins like Puma and NOx which are these antagonize errs of vco2 and activators are back stand back p53 is a tumor suppressor one of the functions is to promote apatow system en't an emerging cancer cell from progressing one mechanism by which p53 does that is by turning on the transcription of Puma and knocks ax and then that will antagonize vco2 and initiate Apatow sious