Peter Attia· MD
typically when you wait until a mouse is two years old to begin calorically restricting it it's too little too late
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
typically when you wait until a mouse is two years old to begin calorically restricting it it's too little too late
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more recent studies that have been done in in some ways more carefully different diets uh certainly if you do a graded onset of caloric restriction in other words don't go right from ad-lib to 40 restriction the next day if you do sort of a graded onset you can get lifespan benefits from caloric restriction you know 20 22 months of age
there's studies, even in mice, that, if you stop it, you lose the benefit.