A hypothetical trial with a 25% placebo success rate and 35% treatment success rate requires 459 participants for 90% power and 358 participants for 80% power.

“so I think that we are going to look at how this drug um you know impacts your rate of surviving a urinary tract infection or being you know cured of this infection and I think that the placebo group is going to have a success rate of 25 percent and I think that the treatment group is going to have a success of 35 percent so I think there's a 10 Gap and I think the lower of those two is 25 percent so you go to 0.25 on the horizontal axis um and you go to 0.1 over on the the column and you'll see there's two numbers there 459 and 358. and the upper of those two is if you want 90 power I.E 10 false negative”