Feedback loops and reverse causation can be issues in Mendelian randomization studies, requiring robust genetic instruments. — Whalespan
Feedback loops and reverse causation can be issues in Mendelian randomization studies, requiring robust genetic instruments.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“the one place that either as an investigator or a consumer of this science where you have to force yourself to look closely as you can be fooled if the randomization of genes meaning if the genes that you're looking at can also control something else that is related to the disease that could have a counterbalancing effect”
“as soon as you have feedback loops you can get phenomenon called reverse causation you can have your genetic instrument also has to be really really good”