Magnesium supplementation may manage migraines by preventing cortical spreading depression and decreasing the release of pain-signaling chemicals.

“Magnesium's potential for managing migraines”

“Five randomized controlled trials suggest that magnesium, at around 600 mg daily, can decrease migraine frequency and severity.”

“I would say one area with respect to the brain where the data is a bit stronger is migraines so ma magnesium might play a role in managing migraines which is a condition that affects many people worldwide there's recent randomized control trials that have really shed some light on magnesium's potential benefits for those suffering from migraines so what is happening in the brain during a migraine one key element is something called cortical spreading depression so it's a kind of wave of brain activity that leads to visual and sensory changes we often associate with migraine or us so interestingly magnesium supplementation seems to help prevent these waves but there's a little more to it magnesium may also decrease the release of certain chemicals in the brain like substance p and glutamate which are known to transmit pain signals so by reducing their release magnesium could play a role in lessening the pain associated with migraines also it”