Paul Saladino· MD
So, if you have MTHFR or other methylation related polymorphisms, maybe avoid the glycinate. Excess glycine uses up methyl groups when it goes out of the body.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
So, if you have MTHFR or other methylation related polymorphisms, maybe avoid the glycinate. Excess glycine uses up methyl groups when it goes out of the body.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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