Deficiency in inositol, which requires magnesium and NAD+, can lead to insulin resistance by impairing glucose uptake.

“even being um deficient in the nositol um which basically when insulin hits its receptor um molecules of anositol get released which is actually what causes glute4 to come up to the cell's membrane and allows glucose to be utilized and burned is actually a nositol compounds so we can deficient in that um which we form from glucose andositol but it requires magnesium and it requires good levels of NAD which can be depleted by inflammation”