Rhonda Patrick· PhD
a meta-analysis of randomized control trials suggested that the use of melatonin is associated with a reduction of tnf-alpha and il-6 levels in chronic inflammatory conditions like in an eight-week randomized control trial with patients with diabetes and also periodontitis supplementation with six milligrams of melatonin per day decreased serum levels of il-6 TNF alpha and high sensitivity C reactive protein which are all biomarkers of inflammation