High doses of melatonin can lead to receptor desensitization and tachyphylaxis. — Whalespan
High doses of melatonin can lead to receptor desensitization and tachyphylaxis.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“There's plenty of good evidence, guys, that when you take melatonin, your receptors are desensitized. So, I actually don't recommend melatonin. If you're having issues sleeping, the first thing you should do is stop looking at your phone at night... I think melatonin is not a good long-term, and it's it's I think it's a more problematic short-term solution to insomnia than people think of.”