Insulin lowers free fatty acids, and the burning of fatty acids contributes to the inability of peripheral tissues to effectively use glucose.

“the insulin in and of itself is having an effect not just by increasing glucose uptake or shuttling things into fat but it's also lowering glucose output by the liver and also lowering free fatty acids which are high in these different states because of the metabolic dysfunction”

“insulin lowers free fatty acids and so the burning of fatty acids as I mentioned before is what's contributing or partially contributing to the inability to effectively use GL glucose in the peripheral tissues”