Glucose levels rarely drop below 2.5-3 millimolar due to homeostatic mechanisms, but insulin levels can drop significantly.

“So glucose is always going to be there, and the body ensures through very powerful homeostatic mechanisms that your glucose is going to stay, rarely go below three, maybe 2.5 millimolar, mine will drop two, go to four and stay within a very tight range, but what does change considerably from a glucose regulation standpoint is the insulin. Insulin bottoms out to the point where I've seen enough blood work to show that in many cases, insulin and IGF-1 is below the reference range.”