The Dené people retained their CPT1 gene on a diet low in carbohydrates and high in meat and fat but lower in PUFAs than the Inuit, suggesting long-term ketosis is not inherently detrimental.

“the neighboring people the den right the people from like the Northern British Columbia also don't have they they eat very they eat much lower amounts of poly andr fats but their diet is mostly meat and fat so they don't have a lot of carbohydrates either right they're eating ruminants and they're presumably in longterm ketosis and they kept their cpd1 Gene”