Fructose metabolism in the liver differs significantly from glucose and ethanol metabolism, involving specific transporters and phosphorylation pathways that can lead to de novo lipogenesis.

“the hepatic glucose metabolism is pretty different than hepatic ethanol metabolism ethanol is alcohol essentially and that's also very different than hepatic fructose metabolism without getting too deep in the weeds here I'll just point out to the listener that there's a glute 5 transporter in the liver which essentially extracts all of the fructose from the circulation fructose is phosphorylated independently of insulin to fructose 1 phosphate by the enzyme fructose kinase”