Peter Attia· MD
vasopressin's not just holding onto water by reducing the excretion the volume of urine but it's also holding onto water by stimulating fat and the way it stimulates fat is through this v1b receptor and we know as this v1b receptor increases cortisol and cortisol of course high cortisol levels can lead to cushing's syndrome where you develop kind of metabolic syndrome so we think that's part of it and it also stimulates glucagon which raises glucose and kind of counter some of the effects of insulin so it acts like it kind of creates an insulin resistant state but also because the fructokinase in the liver seems to go increase in the setting where the v1b receptor is activated and that may help produce more energy depletion by increasing the enzyme so that it can really metabolize the fructose as fast as it can so i think that that's the mechanism